碳纤维汞膜微电极1．5次微分伏安法测定米托蒽醌的研究

Study on Mitoxantrone Using Mercury Film Carbon Fiber Microelectrode by 1. 5 Order Differential Stripping Voltammetry

米托蒽醌（ＭＸＴ）能吸附在碳纤维汞膜微电极表面，阴极溶出时，产生一个灵敏的１．５次微分溶出峰，其峰电流和米托葱酿的浓度在１．０×１０－５ｍｏｌ／Ｌ～１．３×１０－９ｍｏｌ／Ｌ范围内具有良好的线性关系，经３ｍｉｎ的富集，检出限可达１．０×１０－１０ｍｏｌ／Ｌ，据此建立了测定ＭＸＴ的灵敏的新方法，本文讨论了实验条件，并对血样中的ＭＸＴ进行了测定。

Mitoxantrone(MXT) can be adsorbed on the surface of carbon fiber mercury film microelectrode. A sensitive 1. 5 order differential strippins wave peak was obtained during cathodic stripping. The peak current is linear with the MXT solution concentration over range of 1. 0 ×10-5mol/L ──1. 3 ×10-9 mol/L. The detection limit is 1. 0 × 10-10 mol/L, under the 3min accumulation time. Based on these, a new method for determination of MXT has been set up. The experimential conditions were discussed in this paper. The method has been used for the sample analysis with a satisfactory result.