大鼠急性铀中毒的螯合剂治疗

EFFICACY OF CHELATNG AGENTS FOR TREATMENT OF ACUTE URANIUM INTOXICATION IN RATS

本文比较了几种螯合利（８１０２、７６０１、８１１、７６０３、８３０７、ＤＴＰＡ）对大鼠急性铀中毒的治疗效果。结果表明．肌肉注射５００ｍｇ／ｋｇ螯合剂．除ＤＴＰＡ外均有明显的促排铀效果，表现为尿铀排出量增加，肾铀蓄积量降低．其中以８１０２效果最好；８１０２不同时间给药（中毒前１ｈ至中毒后４８ｈ），观察到中毒前１ｈ，中毒后立即及中毒后１ｈ给药均有明显的促排铀效果；８１０２对铀所致肾脏损伤的病理改善，以中毒前１ｈ给药组最佳。此时仅见肾曲管上皮细胞轻度水样变性。

Chelating agents,(8102,7601,811,7603,8307,DTPA)were tested for treatmentof acute uraniurn intoxication in rats, All phenolic chelating agents distinctively increased removal of uranium when thev were injected immediately after intoxication of uranyl nitrate. 8102 was the best of them on removing uranium. After a single i.m. injection of 8102 at doseof 500 mg/kg,the excretion of uranium in the urine was 2.9 times higher than that for control,and the retention of uranium in kidneys was their 29%. When 8102 was administered 1hbefore and up to 4 h after intoxication, it markedly increased the removal of uranium. When8102 was administered to rats 1h before intoxication,the histological lesion in kidneys was only a slight hydropic degeneration of the tubule epithelial cells. On the contrary,there was asevere necrosis of the tubule epithelial cells in kidneys for controls.