SOD对小鼠内污染^（147）Pm损伤机体细胞的防护作用

THE RADIOPROTECTIVE EFFECT OF SOD ON CELLS IN MICE EXPOSED TO ￣(147)Pm

本文用￣３Ｈ－ＴｄＲ掺入技术，研究了小鼠在内污染￣（１４７）Ｐｍ时，超氧化物歧化酶（ＳＯＤ）对受损伤的脾脏淋巴细胞和精子细胞的保护作用。结果表明、在小白鼠受３７ｋＢｑ／ｇ体重的￣１４７Ｐｍ内污染后，ＳＯＤ可不同程度地使脾脏淋巴细胞和精子细胞的￣３Ｈ－ＴｄＲ掺入率增加，非程序ＤＮＡ合成（ＵＤＳ）值增高。表明ＳＯＤ具有对机体细胞ＤＮＡ损伤的保护作用，使损伤细胞的ＤＮＡ合成和修复都得到增强。

In this paper ,the radioprotective effect of superoxide dismutase (SOD) on S-phase DNA synthesis and unscheduled DNA synthesis(UDS)were investigated in spleniclymphocytes and sperm cells of mice exposed to ￣(147)Pm ,which is used as an exciting energy re-source of fluorescent paint. Experimental results show that when the organism was injuredby ￣(147)Pm at 37 kBq/g of body weight,SOD appeared the radioprotective effect.It was notedthat incorporation of ￣3H-TdR in both splenic lymphocytes and sperm cells were increased,which indicates that the S-phase DNA synthesis elevated.At the same time ,a significant in-crease of ultraviolet-induced UDS in splenic lymphocytes and sperm cells was also caused bySOD.