摘要
本文用 ̄3H-TdR掺入技术,研究了小鼠在内污染 ̄(147)Pm时,超氧化物歧化酶(SOD)对受损伤的脾脏淋巴细胞和精子细胞的保护作用。结果表明、在小白鼠受37kBq/g体重的 ̄147Pm内污染后,SOD可不同程度地使脾脏淋巴细胞和精子细胞的 ̄3H-TdR掺入率增加,非程序DNA合成(UDS)值增高。表明SOD具有对机体细胞DNA损伤的保护作用,使损伤细胞的DNA合成和修复都得到增强。
In this paper ,the radioprotective effect of superoxide dismutase (SOD) on S-phase DNA synthesis and unscheduled DNA synthesis(UDS)were investigated in spleniclymphocytes and sperm cells of mice exposed to  ̄(147)Pm ,which is used as an exciting energy re-source of fluorescent paint. Experimental results show that when the organism was injuredby  ̄(147)Pm at 37 kBq/g of body weight,SOD appeared the radioprotective effect.It was notedthat incorporation of  ̄3H-TdR in both splenic lymphocytes and sperm cells were increased,which indicates that the S-phase DNA synthesis elevated.At the same time ,a significant in-crease of ultraviolet-induced UDS in splenic lymphocytes and sperm cells was also caused bySOD.
出处
《辐射防护》
CAS
CSCD
北大核心
1995年第4期302-306,共5页
Radiation Protection
基金
江苏省自然科学基金
关键词
SOD
防护
钷147内污染
机体细胞
Internal Contamination of  ̄(147)Pm,SOD Lymphocytes, Sperm Cells,DNA,UDS,Protective Action