左向右分流先天性心脏病患者及心钠素与肺动脉压力、左心房内径的关系

Relationship between ANP Levels,Pulmonary Arterial Pressure and Left Atrial Dimension in Heart Disease with Left to Right Shunt

应用放射性免疫分析方法检测３５例左向右分流先天性心脏病人（先心组）血浆心钠素（ＡＮＰ）水平，结果先心组较对照组明显升高（Ｐ＜０．０１）；肺动脉高压者显著高于压力正常者（Ｐ＜０．０５）；左心房内径扩大者也明显高于内径正常者（Ｐ＜０．０５）。提示肺循环血容量增多及左心功能状态是影响ＡＮＰ分泌的主要因素，左心房扩大牵张是直接的影响因素。

We studied the plasma levels of atrial natriuretic peptide(ANP)measured by radiometric immunologic analysis in 35 cases of congenital heart disease with left to right shunt.The results showed that ANP levels in this group were significantly increased than those of the normal control group(P<0.01).In these patients,the ANP levels correlated positively with high pulmonary arteiral pressure and increased left atrial dimension (P<0.05).This study shows that increased pulmonary circulatory blood volume is the major factor to increase the plasma level of ANP,while left atrial enlargement and stretch being the direct cause.