急性髓细胞性白血病细胞伴有淋系抗原表达及其临床特点分析

The Clinical Features of the Acute Myeloid Leukemia with Lymphoid Differentiation Antigens Expression

对５６例急性髓细胞性白血病（ＡＭＬ）细胞进行免疫表型测定时发现，８例（１４．２％）ＡＭＬ细胞除表达髓系抗原外伴有淋系抗原表达（Ｌｙ￣＋ＡＭＬ），４８例ＡＭＬ细胞不伴有淋系抗原表达（Ｌｙ￣－ＡＭＬ）。Ｌｙ￣＋ＡＭＬ组于初诊时肝、脾肿大较Ｌｙ￣－ＡＭＬ组常见，外周白细胞数较Ｌｙ￣－ＡＭＬ组高。８例Ｌｙ￣＋ＡＭＬ中仅２例完全缓解（ＣＲ），到达ＣＲ天数多于Ｌｙ￣－ＡＭＬ组。笔者认为Ｌｙ￣＋ＡＭＬ治疗效果差、预后不良，应根据ＡＭＬ免疫表型特点选择合适的化疗方案。

The immunophenotypes and clinical features were investigated in 56 cases of acute myeloid leukemia(AML).Diagnosis was carried out by cytological and cytochemical means,the leukemias were classified according to the FAB classification.8 out of 56 cases(14.2%)AML displayed both myeloid and lymphoid differentiation antigens (Ly￣+AML),48 cases of AML showed pure myeloid antigens(Ly￣-AML).On first visit,Ly￣+ AML grotip showed a higher frequency of hepatosplenomegaly and more white blood cells than the Ly￣-AML group.2 out of 8 cases Ly￣+AML reached to complete remission,days to reach complete remission in Ly￣+AML group were more than those in the Ly￣-AML group.We considered that treatment on Ly￣+AML was difficult,prognosis was bad and the schemes of inducing chemotherapy should be programed according to the features of immumophenotype of AML.