重症急性胆管炎血小板的活化

Activation of Platelets in Severe-typed Acute Cholangitis

动态观察２５例重症急性胆管炎（ＡＣＳＴ）手术前后２周内血小板内游离钙浓度、血小板聚集率、血小板数量等变化。结果显示，血小板在ＡＣＳＴ发病过程中明显活化，血小板细胞内钙离子浓度升高（２３０．５７±４８．３７ｎｍｏｌ／Ｌ），血小板聚集功能下降（１２．８０±３．０４％），血小板数量减少［（２４±５１）×１０９／Ｌ］，且与病情程度和胆道梗阻程度成正比。病情转归后，上述变化恢复正常。血小板活化持续不恢复静息状态，提示病情更严重和预后不良。

The authors observed dynamically the changes of the intracellular free calcium concentrations in platelets,platelet aggregation,platelet counts of 25 cases of ACST pre-and postoperatively.The results revealed that the marked changes of the platelet activity in ACST.It bccurred preoperatively.that the intracellular free calcium concentrations in plalelet increasec,the platelet aggregation decreared,the platelet counts decreased,which is direct proportional to the severity of disease and biliary obstruction.When the patients was recovery,the above changes became normal.If the platelet activity did not recovered persistently,a more severe state and bad prognosis is suggested.