心得安与乙酰甲胆碱气道反应性的对比观察

Airway Responses to Propranolol Compared with Methacholine. in 12 Asthmatic Subjects

作者采用气道吸入不同浓度DL-盐酸心得安测定12例哮喘患者的气道反应性,并与乙酰甲胆碱吸入激发试验进行了对比。结果表明:12例对乙酰甲胆碱激发呈阳性反应,其中11例对心得安也呈阳性反应,阳性率为91.7％,心得安PC_(20)与乙酰甲胆碱PC_(20)无关(r=0.3770,P>0.05),与基础FEV_1也无相关性(r=0.1765,P>0.05),但乙酰甲胆碱PC_(20)与基础FEV_1呈正相关(r=0.6223,P<0.05)。以上结果提示,心得安吸入激发试验可作为非特异性气道反应性测定方法,为哮喘的诊断提供客观依据。其激发机制与乙酰甲胆碱不同,因而在哮喘发病机理和治疗的研究中有不同的意义。

We measured airway responsiveness in 12 asthmatics by propranolol inhalation compared with mcthacholine challenge. All asthmatics responded to racthacholine, of whom 11(91.77%)responded to propranolol as well. There was no linear relationship between PC20 propranolol and PC20 methacholine (r = 0.3770, P>0.05), and between PC20 propranolol and baseline FEV1% predicted (r = 0.176 5, P>0.05). The relationship, however, was found between PC20 methacholine and baseline FEV1% predicted (r= 0.622 3, p<0.05) . The results suggest that propranolol challenge may be used as a method of examining nonspecific airway responsiveness and provide evidence for the diagnosis of asthma. That the mechanism of propranolol challenge differs from that of methacholine challenge, so there is different significance between the two challenges in the mechanism and the research of treatment of asthma.