免疫性疾病患者血清可溶性白细胞介素－2受体水平

Levels of Serum Soluble Interleukin-2 Receptor in Patients with Immune Diseases

采用ＥＬＩＳＡ双抗体夹心法检测１１０例免疫性疾病患者血清可溶性白细胞介素－２受体（ｓＩＬ－２Ｒ）水平，与正常人比较，系统性红斑狼疮（ＳＬＥ）、特发性血小板减少紫癜（ＩＴＰ）、自身免疫性溶血性贫血（ＨＡ）、Ｅｖａｎｓ综合征等病患者血清ｓＩＬ－２Ｒ均有不同程度增高，分别为１３４１．７±５６５．７，１１４３．１±３４７．８，１３３０．９±３５７．０和１４４１．３±９７．２Ｕ／ｍｌ，且与正常对照（４１９．１±２４３．７）间差异存在显著性。ＩＴＰ病人ｓＩＬ－２Ｒ与末梢血小板数量呈明显负相关；ＳＬＥ活动期和非活动期患者ｓＩＬ－２Ｒ差别显著（Ｐ＜０．００１）。认为ｓＩＬ－２Ｒ可作为免疫性疾病诊断、病情监测及反映机体免疫功能状况的一个有用指标。

The levels of soluble interleukin-2 receptor(sIL-2R)were evaluated in the sera of 110 patients with immune disease using enzymelinked immunoadsorbent assay(ELISA).The result showed these patients had high sIL-2R levels as comparing with normal controls.The sIL-2R levels in systemic lupus erythematosus(SLE).idiopathic thrombocytopenic purpura(ITP),hemolytic anemia(HA)and Evans syndrome(ES)patients were 1341.7±565.7 U/ml,1143.1±347.8U/ml,1330.9±357.0U/ml and 1441.3±97.2U/ml respectively.The sIL-2R levels in ITP patients had a negative relationship with the number of peripheral thrombocyte. We also achieved a statistically significant discrimination of slL-2R levels in SLE patients between active and inactive stage.This study suggested that the serum levels of sIL-2R is a useful clinical indicator in prognosing disease,monitoring different phases of disease and reflecting the condition of body’s immune function.