绵羊铅镉中毒及硒解毒的实验研究──血液及心电图分析

LEAD一CADMIUM POISONINGAND DETOXIFICATION OF SELENIUM IN SHEEP:A HEMATOLOGICAL AND ELECTROCARDIOGRAPHIC EXAMINATION

８只绵羊分为两组，饲喂红豆草为主的基础日粮。一为铅镉组，口服１０％醋酸铅溶液（１０ｍｇ／ｋｇ体重／日剂量）和０．４％氯化镉溶液（０．５ｍｇ／ｋｇ体重／日剂量）。二为铅镉硒组，除按上述处理外，另肌注０．１％亚硒酸钠溶液（０．１ｍｇ／ｋｇ体重，一月一次）。实验前健康状态动物设为对照。连续１００天检测血样表明：在实验条件下，Ｐｂ一Ｃｄ中毒绵羊的血液学变化呈现小细胞低色素性贫血的特征。绵羊体内Ｐｂ一Ｃｄ对心肌电活动的影响，主要引起贫血性和心肌损害的心电图改变。依据血液和心电图分析，认为硒可降低（并非抵消）Ｐｂ一Ｃｄ对绵羊的毒性作用。

Eight healthy adult sheep were randomly divided into two groups. Group I was orally dosedwith 10mg Pb+0.5mg Cd/Kg BW per day by using lead acetate and cadmium chloride. Group Ⅱwas injected with 0.1mg Se/Kg BW per month by using sodium selenite,besides the same treat-ment as for Group Ⅰ. The experiment lasted 100 days. The results revealed that the hematologi-cal indices showed a hypochromic and microcytic anemisa and electrocardiographic changes causedby anemia and myocardial damage in Group Ⅰ. However,the above一mentioned indexes werenot significantly different in Group Ⅱ. Hence, it is concluded that selenium injections can detoxi-fy to a certain extent the oral administration of Pb一Cd in sheep.