N－硅甲基－N－甲酰基苯胺衍生物的合成和生物活性研究

Studies on Synthesis and Biological Activities of N-Silylmethyl-N-formyl Aniline Derivatives

研究了醇钠存在下取代苯胺与氯甲基硅烷在二甲基甲酰胺中的反应。反应产物经元素分析、ＩＲ和１ＨＮＭＲ光谱鉴定为Ｎ－硅甲基－Ｎ－甲酰基苯胺衍生物。合成了２３种通式为ＲＲ′Ｒ″ＳｉＣＨ２Ｎ（ＣＨＯ）的新化合物，对其中１７种进行了生物活性试验。结果表明，个别化合物具有良好的杀菌活性，如ｐ－ＦＣ６Ｈ４Ｓｉ（Ｍｅ２）ＣＨ２Ｎ（ＣＨＯ）·Ｃ６Ｈ４Ｃｌ－ｐ在０．００５％即可１００％杀死芦笋茎枯病菌。

In the presence of the reaction of chloromethylsilanes with substituted anilines in DMF was studied. By means of elementary analysis,IR and1HNMR,the products of these reaction are confirmed to be N-silylmethyl-N-formyl aniline derivatives.Twenty-three new compounds(with the general formula:RR'R″SiCH2N·where R=CH3;R'=CH3,p-ClC6H4;R″=p-ClC6H4,p-FC6H4,C6H5;X and Y are H,CH3,Cl,F respectively.)have been synthesized.The biological activities of some compounds have been tested,a few of them have good germicidal activities.thus pFC6H4Si(Me2)CH2N(CHO)C6H4Cl-p at 0.005% gave 100% control of Asparagus stem blight.