摘要
合成了14种含有氮芥结构及芳基取代硫脲基的磷酰胺酯,其结构经1HNMR、IR、MS和元素分析证实。研究了它们的波谱性质及结构和化学位移的关系,讨论了磷原子上取代基对反应的影响.初步生测结果表明,部分化合物具有良好的抗TMV病毒活性和良好的抗肿瘤活性.
In order to look for novel antitumor drugs and virucides with high activity and low toxicity,a series of the title compounds were synthesized by the addition reaction of N,Nbis( 2-chloroethyl)-O-aryl isothiocyanatido phosphoramidate with aryl amine,and their structures were confirmed by spectroscopic and analytical methods. The relationship between the chemical shifts and structures was revealed. The existence of the intermolecular and intramolecular hydrogen-bondings leads to deshielding and to an increase in the frequency of the NMR signal of the hydrogen-bonded protons. Preliminary bioassays indicate that some of them have good inhibitory effects to the growth of different tumor cells such as BGC,HCT,HL60 and BCAP cell lines in human bodies and display a high activity against tobacco mosaic virus(TMV).
出处
《高等学校化学学报》
CSCD
北大核心
1995年第8期1229-1232,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金