N＇，N＇－二－（2－氯乙基）－O－芳基－N^3－芳基硫脲基磷酰胺酯的合成、结构及性质研究

Studies on the Synthesis,Structures and Properties of N',N'-Bis(2-chloroethyl)-O-aryl-N3-aryl Thioureido Phosphoramidate

合成了１４种含有氮芥结构及芳基取代硫脲基的磷酰胺酯，其结构经１ＨＮＭＲ、ＩＲ、ＭＳ和元素分析证实。研究了它们的波谱性质及结构和化学位移的关系，讨论了磷原子上取代基对反应的影响．初步生测结果表明，部分化合物具有良好的抗ＴＭＶ病毒活性和良好的抗肿瘤活性．

In order to look for novel antitumor drugs and virucides with high activity and low toxicity,a series of the title compounds were synthesized by the addition reaction of N,Nbis( 2-chloroethyl)-O-aryl isothiocyanatido phosphoramidate with aryl amine,and their structures were confirmed by spectroscopic and analytical methods. The relationship between the chemical shifts and structures was revealed. The existence of the intermolecular and intramolecular hydrogen-bondings leads to deshielding and to an increase in the frequency of the NMR signal of the hydrogen-bonded protons. Preliminary bioassays indicate that some of them have good inhibitory effects to the growth of different tumor cells such as BGC,HCT,HL60 and BCAP cell lines in human bodies and display a high activity against tobacco mosaic virus(TMV).