藁本内醋和（±）－芹菜乙素的合成研究

Study of Syntheses of Ligustilid and (±)-Sedenenolide

藁本内醋和（±）－芹菜乙素的合成研究李绍白，张少明，李裕林（兰州大学应用有机化学国家重点实验室、兰州大学有机化学研究所，兰州，７３００００）关键词藁本内酯，芹菜乙素，３Ｚ－正丁烯基苯酞藁本内酯（１）和芹菜乙素（２）都属于３－烃基苯酞类化合物。它们广泛...

Z-Ligustilide (1) and sedenenolide (2)are important naturally 3-alkylphthalide analogues occurring in many plants belonging to the Umbelliferae.They have antispasmodic antiasthmatic and smooth muscle relaxing activities.Herein the synthesis of(±)-sedenenolide (2) is described,starting from phthlic anhydride as starting material,The key step in the synthesis is the Birch reduction of 3Z-butylidenephthalide, 3-methyloxy-3-butylphthalide (4)and methyl o-valerybenzoate(3).The yield in this step is 44 %-60%. The synthesis of ligustilide (1) was studied.