N－芳基－异丙胺甲酰基膦酰胺甲酯的研究

Studies on N-Aryl-isopropyl-carbamoyl Methyl Phosphonamidate

Ｎ－芳基－异丙胺甲酰基膦酰胺甲酯的研究陈茹玉，李慧英，任康太（南开大学元素有机化学研究所，天津，３０００７１）关键词膦酰胺，氨基甲酰基膦酸酯，氢键Ｎ，Ｎ－二烷基－氨基甲酰基膦酰胺酯类化合物具有调节植物生长的活性［１］，Ｎ，Ｎ－二烷基－氨基甲酰基膦酸二...

Eight of the title compounds, N-aryl-isopropyl-carbamoyl methyl phosphonamidate(Ⅰ)(i-prNHC(O)P(O)(OMe)NHAr, Ar=substituted phenyl, substituted pyridyl),were synthesized by reacting the phosphonyl chloride with arylamine under a mild condition in order to study the method of the synthesis of this kind of compounds and look for efficient antiviral drugs and pesticides. The preliminary bioassay showed that the title compounds had little bioactivity. The structure of the compounds had been studied and 1H NMR showed that there were two kinds of inter-molecular hydrogen bondings in the compounds.