依那普利与卡托普利对原发性高血压降压疗效的动态血压观察

Comparative Study of Enalapril and Captopril in the Treatment of Essential Hypertension

对50例轻、中度高血压（EH）患者用依那普利（5mg，4／d）和卡托普利（2.5mg，2／d）口服做单盲平等两组对照研究。治疗4周结果两组总有效率相似（分别60.6％，65.2％，P＞0.05），无论SBP和DBP均值的下降均明显（P＜0.05～0.001）。但对每组各抽5例的24h动态血压监测治疗前后比较，依那普利组24h血压控制均较满意，而卡托普利组白天血压控制满意，但夜晚又翌晨血压与治疗前接近（P＜0.05）。如昼夜血压均高者，选用依那普利等长效制剂为佳，如夜间血压正常者，可用卡托普利治疗，唯晨剂应在睡醒后即服为宜。

Comparative study of enalapril and captopril was carried out on fifty patients with mild and moderate essential hypertension（EH）.Treatments were continued for 4 weeks in a single-blind,randomized,parallel design.Total effective rate in two groups were 60.0％ and 65.2％ respectively（P＞0.05）.Five patients in each group were studied by 24h-ABPM.In enalapril group the day-time BP was controlled satisfactorily（P＜0.05～0.01）but not in captopril group,in which the late night and early morning BP were close to the pretreatment level（P＞0.05）.We recommended that in patients with nocturnal hypertension,the long durable effective agent （such as enalapril 2／d） should be prefered.In patients without nocturnal hypertension the short halflife agent（captopril 2～3／d） seems to be the first choice.Because of a morning arouse of BP,it is recommened that captopril should be taken before getting up.