摘要
对50例轻、中度高血压(EH)患者用依那普利(5mg,4/d)和卡托普利(2.5mg,2/d)口服做单盲平等两组对照研究。治疗4周结果两组总有效率相似(分别60.6%,65.2%,P>0.05),无论SBP和DBP均值的下降均明显(P<0.05~0.001)。但对每组各抽5例的24h动态血压监测治疗前后比较,依那普利组24h血压控制均较满意,而卡托普利组白天血压控制满意,但夜晚又翌晨血压与治疗前接近(P<0.05)。如昼夜血压均高者,选用依那普利等长效制剂为佳,如夜间血压正常者,可用卡托普利治疗,唯晨剂应在睡醒后即服为宜。
Comparative study of enalapril and captopril was carried out on fifty patients with mild and moderate essential hypertension(EH).Treatments were continued for 4 weeks in a single-blind,randomized,parallel design.Total effective rate in two groups were 60.0% and 65.2% respectively(P>0.05).Five patients in each group were studied by 24h-ABPM.In enalapril group the day-time BP was controlled satisfactorily(P<0.05~0.01)but not in captopril group,in which the late night and early morning BP were close to the pretreatment level(P>0.05).We recommended that in patients with nocturnal hypertension,the long durable effective agent (such as enalapril 2/d) should be prefered.In patients without nocturnal hypertension the short halflife agent(captopril 2~3/d) seems to be the first choice.Because of a morning arouse of BP,it is recommened that captopril should be taken before getting up.
出处
《高血压杂志》
CSCD
1995年第3期227-228,共2页
Chinese Journal of Hypertension
关键词
原发性
高血压
依那普利
卡托普利
动态血压
essential hypertension,ACE-inhibitors,enalapril,captopril,ammbulatory blood pressure monitoring