尼群地平对高血压患者左室舒张功能和细胞内钙浓度的影响

Effects of Nitrendipine on Left Ventricular Diastolic Function and Intracellular Calcium Concentration in Essential Hypertensive Patients

观察23例高血压患者尼群地平治疗4周后舒张功能指标、淋巴细胞内钙浓度、红细胞膜Ca^（2+）-ATP酶和血浆钙调素（CaM）的变化。结果显示,尼群地平可增大E/A比值、快速充盈分数和1/3充盈分数,减小A峰流速、房缩期充盈分数和左房内径。提示尼群地平可改善左室舒张功能;尼群地平降低细胞内钙浓度,并与左房排空指数和1/3充盈分数增大呈正相关。提示尼群地平降低细胞内钙与改善左室舒张功能可能有一定关系;尼群地平降低红细胞膜Ca^（2+）-ATP酶活性,但不改变CaM活性,提示尼群地平减少细胞内钙浓度并不通过提高钙外流。

Effects of 4 weeks nitrendipine treatment on diastolic functional indexes, intra-lymphocyt-ic calcium concentration, erythrocyte membrance Ca2+-ATPase and plasma calmodulin in 23 essential hypertensives were studied. The results showed that nitrendipine increases E/A ratio,rapid filling fraction and 1/3 filling fraction, decreases A peak velocity and atrial filling fraction and left atrial diameter,and improves left ventricular diastolic function. Nitrendipinelowered intracellular calcium concentration, which is negatively related to the increases in left atrial emptiness and 1/3 filling fraction. Nitrendipine also lowered erythrocytic membrane Ca2+-ATPase activity but did not change the plasma calmodulin activity,indicating that lowered intracellular calcium by nitrendipine may not be ascribed to the increase outward of calcium ions.