原发性高血压病因的多因素研究

Multiple Etiology Study of Essential Hypertension

对39个家系父母二系三级亲属及无血缘关系亲属中15岁以上成人共937人高血压有关危险因素进行调查。资料经单因素分析、剂量效应分析及多因素非条件Logistic回归分析。结果表明,作为遗传标志的血缘关系与年龄、体重、饮酒、文化程度等5个因素对高血压发生有显著影响,这些因素可以认为是本次研究中高血压发病的主要危险因素。交互效应分析发现,两两因素相结合可出现相加模型的增效作用。

We investigated some risk factors for hypertension in 39 probands and their first, second and third degree relatives as well as nonconsan-guineous relatives. The data were analysed by single factor analysis, dose-response relationship analysis and multivariate unconditional logistic regression analysis. The results showed:the risk factors related to the development of hypertension in our study were consanguineous relation, age, overweight, drinking, e-ducation status and occupation. In addition, an additive synergic model was found when the two risk factors were combined.