摘要
１９９１年３月～１９９４年３月，我院在全麻低温体外循环下行风湿性心脏病心内直视换瓣２３例，均用人工机械瓣，由于人工瓣膜的血液相溶性差，术后血栓栓塞率高，需终身抗凝。我们在抗凝治疗中体会到：服用华法令后显现的个体差异大，服药量与体重无明显关系，某些药物可影响华法令的抗凝作用，高原缺氧对华法令的代谢有一定影响。
3 cases with RHD received in tracarkiac vafve
replacdment by hypothetmic CPB under generalanesthesia at Mar.1991 to
Mar1994.All of them used mechanical valve prosthesis,but the
postoper-arive incidence of thromoboembolism was high and
anticoagulaiit the rapy was needed because theblood compatibility of
artificialvalve was wrong.Our experience is that the considerable
individual dif-ference is showed after using warfarin;the correlation
between dose and body weight is not obvious;some medicine may
influence anticoagulant effect of warfarin; and altitude bypoxia
shows a definite in-fluence on metabolism of warfarin.
出处
《高原医学杂志》
CAS
1995年第2期28-30,共3页
Journal of High Altitude Medicine
关键词
心脏瓣膜替换术
抗凝治疗
高海拔
cardiac valve replacement
anticoagulant therapy
high altitude
