藏药唐古特青兰的抗缺氧及其它作用

THE ANTIHYPOXIC EFFECT OF DRACOEPHALUM TANGUTICUM MAXIM

藏药唐古特青兰（ＤｔＭ）水提液ｉｐ可极显著地降低小白鼠整体耗氧量，还可延长异丙肾上腺素所致小鼠心肌损害的存活时间，对心肌可能有一定的保护作用；另外ＤｔＭ可对抗由于ＫＣＮ和ＮａＮＯ＿２所致的小鼠组织中毒性缺氧，有效地延长小鼠存活时间；同时Ｄｔｍｉｇ还具有明显抗寒冷作用，但实验中ｉｐ和ｉｇ给药均未发现抗疲劳作用和耐高温作用，揭示ＤｔＭ不是一种好的致适应剂，但其显著的抗缺氧作用值得我们深入探讨。其ｉｐ和ｉｇ给药的ＬＤ＿（５０）分别为１８．８±０．６ｇ／ｋｇ和１４２．３±４．２ｇ／ｋｇ（Ｐ＝０．９５）

n our study,the aqueous extracts of Dracocephalum tanguticum Maxim(DtM).a Tibetan medicine,could significantly reduce the oxygen consumption of mice by intraperitoneal injection of 2. 5g/kg and 5.0g/kg(P<0.01)and rersist the toxic hypoxia of tissaues resulted from KCN and NaNO_2,therefore,the survival time of mice were extended effectively,In the 5.0g/kg group,the effects were more obvi-ous than the 2.5g/kg group(P<0.001).The DtM extracts also showed apparent antifrigid ability inmice with endogastric administration,but antifatigue and heat resistin effects were not observed nei-ther by intraperitoneal nor endogastric administration.The results indicated that the DtM is not a sat-isfied adaptogen,but its obvious antihypoxic effect is worth studying further.In addition,the LD_(50) inintraperitoneal and endogastric ways were 18.8+0.6g/kg and 142.3+4.2g/kg respectively(P=0.95)。