中度高原地区正常及妊高征孕妇超氧化物歧化酶和丙二醛水平的初步研究

A STUDY ON SOD AND MDA DURING PREGNANCY WITH AND WITHOUT GESTIONAL HYPERTENSION AT HIGH ALTITUDE

本文测定了未孕妇女、正常孕妇和妊高征孕妇的超氧化物歧化酶（ＳＯＤ），丙二醛（ＭＤＡ）和维生素Ｅ（ＶＥ）水平。结果为正常孕妇ＳＯＤ低于未孕妇女，而ＭＤＡ和ＶＥ高子未孕妇女（Ｐ均＜０．０１），提示孕妇抗氧化能力可能增强。妊高征孕妇与正常孕妇相比，ＳＯＤ、ＶＥ更低（Ｐ＜０．０１），而ＭＤＡ则更高（Ｐ＜０．０５），而且妊高征孕妇的ＭＤＡ与ＳＯＤ、ＭＤＡ与ＶＥ呈负相关（ｒ＝－０．９５６，－０．７０４８、Ｐ＜０．０５），提示可能有脂质过氧化反应的增强和氧化能力下降，为妊高征的急性动脉硬化提供了条件。

uperoxide dismutase(SOD),Vitamin Eand malondialdehyde (MDA)Were investigated innon-Peregnant(NONP),normal pregnant(NORP),abnormal pregnant(gestional hroertension)(ABNP)women at 2 260m high altitude. The results showed that SOD in NORP was lower thanNONP,but their ,MDA and vitamin E were higher than NONP.SOD and vitamin E in ABRP were lower(P<0.01),but MDA was higber(P<0.05)thanNOKP.IN ABRP MDA and SOD,MDA and vitamin E showed a negative correlation(r=n0.956,-0.7048,P<0.05,respectlvely).The results suggested that the antioxidation in NORPmight be increased,in ABRP the lipid peroxidation might be increased but antioxidation de-creased.The results indicated that the changes of SOD and MDA at high altitude might relatewith acute arteriosclerosis in the pregnant women with gestional hypertension,for which futherstudy is needed.