碳纤维复合材料粉尘对大鼠肺致纤维化作用的实验研究

PULMONARY FIBROGENICITY OF CARBON FIBER COMPOSITE DUST IN RATS

采用气管注入染尘技术探讨了碳纤维复合材料（ＣＦＣ）粉尘对大鼠肺的致纤维化作用，另设石英（阳性对照）和二氧化钛（阴性对照）组与之比较。结果表明：染ＣＦＣ粉尘大鼠肺脏初期病变为异物性肉芽肿反应，后期ＣＦＣ粉尘在肺内形成黑色斑块，但无纤维组织增生，斑块周围肺泡明显扩张，肺纤维化反应的强度与二氧化钛粉尘接近。其病变特征又类似于碳素性粉尘，唯纤维化程度比其轻。所获结果为制订ＣＦＣ粉尘卫生标准提供了实验依据。

Dust intratracheal injection technique was used to evaluate the pathogenicity for carbon fiber composite(CFC)dust in rats,Quartz (positive control) and titanium dioxide(negative control)were used for comparison. In the early stage,CFC dust in the lungs provoked a foreign body granuloma reaction, Up to the later stage, CFC dust formed black maculae in lungs without collagenous reaction, Around the maculae marked alveolar dilation emerged. The fibrotic grade produced by CFC dust was similar to that in the control rats injected with titanium dioxide, The pathological feature was similar to that seen in the rats exposed to other carbon dusts except for the slighter fibrosis caused by carbon dusts. This investigation may provide experimental evidence for the health standard setting of CFC dust.