碳纤维粉尘对大鼠肺脏致纤维化作用的实验研究

PULMONARY FIBROGENIC EFFECT OF CARBON FIBER DUST IN RATS

采用气管注入染尘法探讨了碳纤维（ＣＦ）粉尘对大鼠肺脏的致纤维化作用，并以ＵＩＣＣ温石棉和ＳＡＦＦＩＬ无机纤维为阳性和阴性对照。病理检查结果显示，染ＣＦ粉尘大鼠各观察期肺内病变轻，１年后肺内仅有粉尘细胞灶形成，灶内未见胶原纤维增生。ＳＡＦＦＩＬ组大鼠肺内病变与之接近，而温石棉组大鼠６个月就发生了明显的肺纤维性变，ＣＦ粉尘也未明显引起大鼠体重增长降低和肺湿重增加。ＣＦ直径租，属非呼吸性纤维粉尘，较短的ＣＦ易被清除，较长的ＣＦ亦未引起肺组织纤维增生。据此并从对呼吸道的影响推测，目前ＣＦ生产条件下产生的粉尘不会给工人带来明显危害。

Intratrachea 1 instillation of dust was used to evaluate the pulmonary fibrogenicity for carbon fiber dust in rats. UICC chrysotile and SAFFIL inorganic fibers were used as positive and negative controls respectively. Histological examination revealed that CF dust produced only relative slight changes. The maximum reaction consisted of dust cell foci alone without collagenous formation over a period of one year. SAFFIL fiber dust gave similar findings to those of CF dust, whereas severe fibrosis was noted in chrysotile injected rats only six months after administration. Besides, CF dust did not obviously result in the loss of body weight and the increase of lung weight. CF used in this investigation was a non-respirable fiber with coarser diameter. As shown in histological observation the smaller particles were more readily eliminated and the larger particles did not produce a detectable collagenous lesion as well. It is then estimated that under current condition in CF production CF dust in the air of workplaces would not induce evident respiatory hazard to the workers.