β－环糊精与阿斯匹林包合反应的热力学研究

Study on the Thermodynamic Property of Aspirin by Inclusion Complexation of β─Cyclodextrin

利用β─环糊精（β─ＣＤ）的特性，制备了阿斯匹林─β─ＣＤ包合物，经粉末Ｘ射线衍射法进行鉴定，确证为包合物。通过测定不同浓度β─ＣＤ水溶液中阿斯匹林的溶解度，确定其溶解度相图为Ａ＿Ｌ型，进而计算其热力学参数Ｋ、△Ｇ￣ｏ、△Ｈ￣ｏ、△Ｓ￣ｏ．初步探讨了包合作用的原动力。

The formation of aspirin─β─cycledextrin inclusion complex was propared andconfirn1ed by X-ray diffraction. The equillibrium association constant(K)and the thermedy-namic parameters △G°,△H° and △S°were calculated.And the interaction power or the inclu-sion complexation was predicted.