纳洛酮治疗急性酒精中毒

TREATMENT OF ACUTE ALCOHOLTSM BY NALOXONE

本文收治急性酒精中毒患者２０例，随机分为两组，治疗组１０例用纳洛酮治疗，对照组１０例，两组性别，年龄，饮酒量，饮酒至来院时间及病情程度光显著差异（Ｐ＞０．０５）。治疗组应用盐酸纳洛酮０．４～１．２ｍｇ静推或静滴，平均显效时间１２．７分钟，症状减轻时间３２．４分钟，症状消失时间７３分钟，与对照组比较差异有显著性（Ｐ＜０．０１）。治疗组无１例出现副作用。证明纳洛酮是治疗急性酒精中毒新的有效药物。

Abstract Twenty cases of acute alcoholism were equallysivided at random into two groups with oneof them treated with Naloxone and the otherserving as contrast.The two groups had nosignificant difference (P>0.05) in sexes, ages, theamount of drink,the duration from drinking tohospitalization and the seventy of the patients'conditions.A dose of 0.4￣l.2 mg of Naloxonewas administered to each patients in The treated group by intravenous injection or intravenousdrip.The time for the drug to take effect averaged 12.7 minutes. The time for the symptomsto alleviate was 32.4 munites and for the symptoms to disappear was 73 minutes.There was amarked difference (p<0.01) in this respect betweenthe two groups.Not a single case in the treatedgroup showed any side effects.This is an evidencefor the application of Naloxone as a new drugto the treatment of acute alcoholism.