自体LAK细胞制备及其在临床上的应用

AUTOLOGOUSLAK CELLSPREPARATION AND ITS USAGEIN CLINIACAL PRACTICE

以基因重组白细胞介素Ⅱ（ｒＩＬ－２）诱导患者自体ＬＡＫ细胞。使用ＬＡＫ／ｒＩＬ－２治疗３例经病理或临床确诊为妇科晚期恶性肿瘤患者。ＬＡＫ细胞（２．２～３．１）×１０９／ｒＩＬ－２１．６×１０６单位治疗一个疗程。治疗前后用Ｂ超、Ｘ线平片观察肿块变化。结果显示，１例癌肿块明显缩小（ＰＲ），１例肿块缩小（ＭＲ），１例肿块无改变（ＳＤ）。患者主观症状改善，生活质量提高。除１例病人在治疗时出现一过性发热外，未见其他毒副作用。

Autologous lymphokine activated killer(LAK) cells were induced byrecombinant interleukin-2(rlL-2).Three patients with advanced gyneacology cancer weretreated with LAK and rIL-2 Autologous LAK cells(2.3～31×109)and rIL-2(1.6×106units)were returned to each patient via intravenous transfusion during a course of treatment Aftertreatment。the sizes of the tumors were evaluated by B-ul trasonic and X-ray examination and were comparied with those before treatment The tumor bulk in one patient reduced in size dis-tinctly(partial response,PR),some reduction(minor rexponse,M R)in the other pantient and no change(steady,SD)in the third patient.In aditlon,the subjective symptoms of the oatients were improved.During treatment no side effects were observed except one patient had had a transient fever after the infusion of autoloEous LAK cells。