结核病变组织中的抗体反应

ANTIBODY REACTION DEMONSTRATEO IN HUMAN TUBkKCUL OUSTISSUES

应用免疫组化技术，检测了２５例结核病人４９块病变组织中的减毒牛型结核杆菌（ＢＣＧ）抗原、ＩｇＧ、ＩｇＭ、ＩｇＡ及补体Ｃ３ｃ。结果：在大多数结核病变组织中可检测到ＩｇＡ、ＩｇＭ等物质，而以淋巴结的阳性反应较高。ＩｇＧ与ＩｇＭ染色阳性反应分别为８９％（２４／２７）与８７％（１３／２５）。抗－Ｃ３，抗ＩｇＧ、ＩｇＭ等阳性反应物常见于同一结核病灶，ＩｇＭ抗体阳性多位于干酪样坏死灶。研究表明，在结核病的发病过程中，除细胞免疫外，还有体液免疫参与，并表明ＩｇＭ之免疫复合物可能与干酪样坏死的形成有关系。

BCG antigen,IgG,IgM,IgA and C3c were detected in 49 tissue blocks from 25tuberculosis patients by means of immunohistochemical staining.C3,IgG and lgM were presentin the majority of the specimens,particularly in the lymph nodes.The positive rate for IgG andIgM in the lymph nodes were 89%(24/27)and 87%(13/15)respectively.Frequently,C3,IgGand lgM were present at the same sites.IgM antibodies were most frequently located in thecaseation areas.Our results indicated that besides cellular immunity,humoral immunity may al-so play a role in the pathogenesis of the changes in tuberculosis,and that IgM antibody associ-ated immune complex may be involved in the formation of caseation。