急性肾小球肾炎红细胞膜流动性的变化

ERYTHROCYTE MEMBRANE FLUIDITY CHAN-GES IN CHILDREN WITH ACUTE GLOMERULONEPHRITIS

测定２０例急性肾小球肾炎（ＡＧＮ）患儿急性期和恢复期血浆脂质过氧化物（ＬＰＯ）、红细胞膜微粘度。结果表明：血浆ＬＰＯ、红细胞膜微粘度在急性期明显升高，恢复期接近正常；急性期并发急性肾功能衰竭（ＡＲＦ）患儿血浆ＬＰＯ、红细胞膜微粘度明显高于未并发ＡＲＦ患儿；血浆ＬＰＯ和红细胞膜挞粘度呈有意义的正相关。提示：检测红细胞膜的流动性有助于估计ＡＧＮ病情轻重；氧自由基引发膜脂质过氧化导致红细胞膜流动性降低，造成肾脏微循环障碍，这对ＡＧＮ发病机制的探讨具有重要意义。

Plasma lipid peroxide(LPO)and erythrocyte membrane microviscosity。in 20children with acute glomerulomephritis were determined in the acute and recovery stage of thedisease.The resuIts showed that LPO and erythrocyte membrane microviscosity were markedlyincreased in the acute stage,but were aimost normal in the recovery stage,LPO and membranemicroviscosity of the patients with acute renal failure were higher than those without acute renalfailure,There was a significant positive correlation between the LPO and membranemicroviscosity changes of the patients.The results suggest that:①determination of theerythrocyte membrane microviscosity may help to evaluate the clinical conditions of the childrenwith acute glomerulonephritis;mcmbrane lipid peroxidation and the resulting decrease in theerythrosyte membrane fluidity may lead to the disorder of the renal microcirculation。