对氨基水杨酸钠治疗慢性锰中毒机制的研究

A STUDY ON THE EFFECT OF TREATINGMANGANESE POISONING WITH SODIUMPARA-AMINOSALICYLATA ACID

用对氨基水杨酸钠(PAS-Na)治疗用氯化锰腹腔注射的大鼠和小鼠。结果:过量锰对动物机体的毒性表现为多个系统的异常反应,但用PAS-Na治疗后,能降低其血液和各器官(脑、肝、肾)组织中过量蓄积锰的含量;能增加其胆汁和粪中锰的排出量;能使被过量锰所影响动物的行为、免疫功能、酶活性、脑神经递质水平以及脑组织学等改变恢复正常或接近正常。揭示PAS-Na对治疗慢性锰中毒具有明显疗效。

In traperitoneal injections of MnCl24H2O produced functional disturbances in several systems of the rats and mice. Such manganese poisoning was treated with Sodium Fara-aminosalicylate Acid (PAS-Na). After subehronic treatment, the manganese content in the blood and tissues decreased. While the manganese content in the bile and feces increased. The behavior of the animals, functions of the immune system,activity of the enzymes, level of the monoaminoneurotransmitter and the histology of the brain, which were af-fected by excessive manganese might be restored to normal or nearly normal. The results indi-cate that PAS-Na appears to be an effective drug for the treatment of chronic manganese pois.