摘要
兔2细胞期或8～16细胞期胚胎培养液立即或经冷冻、鲜冻后注入去脾小鼠体内,能异源性引起去脾小鼠血小板数量显著减少(P<0.050)。血小板激活因子受体竞争性拮抗剂海风藤酮能抑制这种作用。试验说明兔胚胎释放血小板激活因子,并引起去脾小鼠血小板的聚集。
Splenectomized mice were injected fresh or frozen-thawed 2-cell or 8-16-cell rabbit embryo- cultured medium.Rabbit embryo-cultured medium could cause a significant decrease(P<0.050)in platelet number of heterogeneous of splenectomized mice.Kadsurenone which is a competitive antagonist of platelet activating factor(PAF)receptor could inhibit this effect.Experiments illustrated that rabbit embryos released PAF and induced platelet aggregation of splenectomized mice.
基金
本研究为国家自然科学基金
关键词
兔胚胎
去脾小鼠
血小板
激活因子
海风藤酮
rabbit embryo
splenectomized mouse
platelet activating factor(PAF)
kadsurenone
