摘要
2-苯亚甲基-3-丁酮酸乙酯与芳香胺和w=37%甲醛水溶液或芳胺和甲醛的缩合物在氯化氢-无水乙醇存在下可直接发生的Mannich反应,得到1-对位取代芳基-2-苯基-3-羰乙氧基-哌啶-4-酮。共合成了6个新化合物,产率为47%~61%,用IR,1HNMR,13CNMRMS和元素分析确定了结构。
In the presence of ethanol- HCl solution, arylamine-HCl and w=37% aqueous formaldehyde solution or the condensation product of arylamine and formaldehyde are directly reacted with ethyl 3-oxo-2-phenylmethylenebutyrate to form l-aryl-2-phenyl-3-carbethoxy-4-piperidone. Six new compounds are prepared by this method, yield from 47%~61%. The structrue is deduced by IR, 1HNMR, 13CNMR, MS and elemental analysis .
出处
《北京师范大学学报(自然科学版)》
CAS
CSCD
1995年第3期373-376,共4页
Journal of Beijing Normal University(Natural Science)
关键词
MANNICH反应
苯亚甲基
丁酮酸乙酯
芳香胺
Mannich reaction
ethyl 3-oxo-phenylmethylenebutyrate
l-aryl-2-phenyl-3-carbethoxy-4-piperidone
structural analysis