AMS／5近交系小鼠培育及其生物学特性的研究

Breeding of AMS/ 5 Indred Strain Mouse and its Biological Properties

近交纯系动物具有一致的基因型和遗传特征，个体之间差异极小，实验中容易取得一致的结果［１．２］.随着医学科学研究的飞速发展，近交系动物的培育及应用愈来愈被人们所重视，为适应不同课题研究需要而培育的近交系动物的品系越来越多.由于各种原因，国内开展这项工作较晚，长期以来我们缺少更多合适的近交动物品系来进行大量生产和供应.我院于１９７４年３月起从封闭群ＬＡＣＡ小鼠中选留亲本，进行严格的近亲同胞兄妹交配，宗旨是建立一株没有生理缺陷，遗传背景一致，体格健壮，繁殖能力强的近交系小鼠［２．３］．其中ＡＭＳ／５系繁殖线以繁殖力较强为选种指标保存下来，进行严格的近交纯化育种.至今已达Ｆ５３代.经过遗传品质检测已达基因纯合，符合近交系的要求.

AMS/5is a new inbred strain mouse which ancestor came from the closed colony LACA mice.Currently, the strain have reproduced to fifty-three generations;Coat color gene tests of the mice with white hair show that the coat color gene is AABBccDD, Genetic monitoring including skin graft.biochemical markers, chromosome marker corresponses to the inbred strain standard.The reproductive performances are as following:The litter size is 7.5(5-8).weaning rate s 95%(except the first litters).The adult mice weight l8.97±l.04g for female and 21;60±l.68g for male. Serum IgG increases with the old of ages.Themice have been widely used in medical research fields such as in the radiation medicine, immunology, and toxiology. It is a new kind of amimnal model for medical experiments.