楔状核内微量注射谷氨酸对中缝大核痛放电的影响

EFFECT OF GLUTAMIC ACID MICROINJECTED INTO NUCLEUS CUNEINFORMIS ON THE DISCHARGES OF PAIN EXCITATION NEURONS IN NUCLEUS RAPHE MAGNUS OF RATS

用玻璃微电极细胞外记录法，探讨楔状核内注入胞体兴奋剂谷氨酸对中缝大核内痛兴奋性神经元痛放电的影响。结果表明，楔状核内注入谷氨酸可明显抑制中缝大核内痛兴奋性神经元痛放电。示楔状核内神经元与抗伤害感受作用有关。

Extracellular recording technique was used to investigate the effect of a neuron excitant,glutamic acid applied by microinjecting into nucleus cuneinformis(NCF) on the evoked discharges of pain excitation neurons (PEN )in nucleus raphe magnus (NRM).We found that glutamic acid microinjected into NCF could inhibit the pain evoked discharges of PEN in NRM markedly. The result suggests some NCF neurons may play a role in mitigating the sense of nociception