环丙沙星软膏治疗创面细菌感染的实验研究

The Experimental Study of Ciprofloxacin Unguentum for Bacteritic Infection of Wound

用环丙沙星软膏治疗小鼠创面细菌感染，结果表明该药对金黄色葡萄球菌、溶血性链球菌以及绿脓杆菌感染均有明显的治疗作用，能有效和迅速地抑制细菌，促进创面的愈合；本药疗效明显优于对照药物诺氟沙星乳膏、红霉素软膏以及磺胺嘧啶银盐软膏。

Ciprofloxacin unguentum is a new antimicrobial.It has broad spectrum of activities against gramnegative and gram-positive bacteria in vitro. The treatment action of the drug was studied in mice by us.We made the infectious models of Staphy. aureas and Strep. hemolyticus after wound,and the infectious model of Ps. aeruginosa after scald in mice. Ciprofloxacin unguentum was given by local administration for 4 days continuously(2 time/day).In the meantime, Norfloxacin cream,Erythromycin unguentum and Silver sulfadiazine unguentum were given as contrast.A sample from tissue under the crust was took for quantitative examination of bacteria every day.The animal experimental results showed that Ciprofloxac in unguntum effectively and quickly inhibit Staphy.aureas,Strep.hemolyticus and Ps. aeruginosa under the crust,and markedly promote healing of wound.The above-mentioned actions of Ciprofloxacin unguntum are markedly higher than that with Norfloxacin cream, Erythromycin unguntum and Silver sulfadiazine unguentum.