61例肾脏病患者血清唾液酸含量的测定

Measurements of serum Sialic Acid in 61 Cases of Patients with Renal Disease

测定了６１例肾脏病患者血清唾液酸（ＳＡ）含量。结果发现：肾病综合征、慢性肾功能不全、肾炎综合征及慢性肾盂肾炎的ＳＡ均值均显著高于正常（Ｐ＜０．００１）。并发现肾病综合征ＳＡ与补体Ｃ_３呈显著性负相关（Ｐ＜０．０５），肾炎综合征ＳＡ与补体Ｃ３、ＣＨ５０呈显著性负相关（Ｐ＜０．０５），慢性肾功能不全ＳＡ与２４ｈ尿蛋白定量呈显著性负相关（Ｐ＜０．０５）．表明肾病综合征、肾炎综合征ＳＡ增高可能与严重的免疫功能紊乱有关，慢性肾功能不全ＳＡ增高可能与多种因素抑制蛋白滤出有关。

Serum Sialic Acid(SA)was measured in 61 patients with renal disease.The results showed that the concentration of serum SA was 433.97±66. 45 ng/L in the controls(30 cases),559.44±72.19 ng/L(P<0.001),558.93±141.48 ng/L(P<0.001),553.71±88.21 ng/L(P<0.001),562.10±105.77 ng/L(P<0.001) in the patients groups with nephrotic syndrome(9 cases),chronic renal failure(15 cases), nephritis syndrome(17 cases)and chronic pyelonephritis(20 cases ).Nephrotic syndrome of te serum SA had a negative correlation with serum C3(1 158.11±301.32mg/L,r=-0.5141,P< 0.05). Nephritis syndrome of the serum SA had a negative correlation with serum C3(756.06±437.58mg/L,r=-0.644 9,P<0.05) and CH50(74.94±29.52 kU/L,r=-0.447 5, P<0.05), chronic renal failure of the serum SA had a negative correlation with 24 h urine protein(2 170.69±1186.85 mg/24 h,r=-0.513 5,P<0.05). The date indicated that the abnormal level of the plasma C3,CH50 plays a role in the nephrotic syndrome and nephritis syndrome of the serum SA markedly higher, the abnormal level of 24 h urine protein plays a role in the chronic renal failure of the serum SA markedly higher.