服用抗氧化剂降低老年人血清脂质过氧化物——随机双盲临床试验

THE REDUCTION OF SERUM LIPID PEROXIDES IN ELDERLY POPULATION BY ORAL SUPPLEMENTATION OF ANTIOXIDANTS

给某老年人护理院的45位老人服用β-胡萝卜素,维生素B_6,维生素C,维生素E,锌和硒,或者相应的安慰剂作为日常食物的补充,为期一年。开始时,这些老年人的血清脂质过氧化物水平(2.7±0.7μmol/L)高于作为对照组的年轻健康成年人(2.3±0.6μmol/L),P<0.01。服药三个月后,老年人的血清脂质过氧化物已降至2.2±0.6μmol/L,并且保持这一低水平直到研究结束,而服安慰剂者血清脂质过氧化物无变化。 血清脂质过氧化物与全血硒浓度呈显著负相关(r=-0.428,P<0.01),但只有在血硒高于200μg/L时才可见血清脂质过氧化物的降低。血清α-维生素E浓度也与血清脂质过氧化物呈负相关,但相关程度(r=-0.273,P<0.76)低于与血硒间的相关。 从生物化学角度看,25％的老年人可观察到维生素B_6缺乏;每天补充2mg维生素B_6彻底治愈了全部的病例。服药组经几项心理学检验有轻微改善,而服用安慰剂的对照组无变化或者恶化。护士报告在服药组中见有临床改善,未见有毒性副作用。老年人服用抗氧化剂从生物化学和临床上都是有益的。

An <<antioxidant cocktail>consisting of betacarotene, vitamin B8, C, E, zinc and selenium or corresponding placebos were given for one year as daily dietary supplements to 45 elderly residents of an old people's nursing tome. Initially, the serum lipoperoxide levels were higher (2.7±0.7 μmol/L) than those of an ad hoc control group of 31 healthy younger adults (2.3±0.6μmol/L, p<0.01). After three months supplementation, the lipo-peroxides in the serum of the elderly decreased to 2.2±0.6μmol/L (p< 0.01), and they remained at this lower level until the end of the study period, while the placebo group showed no change. A significant inverse correlation (r = 0.428, p<T0.01) existed between the concentrations of serum lipo-peroxides and whole blood selenium (B-Se), but only B-Se levels above 200 μg/L resulted in a decrease in scrum lipid peroxides. Serum alpha-tocophe-rol concentration also correlated inversely with serum lipoperoxides, but this correlation (r = 0.273, p= 0.076) was not as strong as that of B-Se. Deficient vitamin B6 status, in biochemical terms, was observed in 25 per cent of the elderly; a daily supplement of 2 mg B6 fully cured all cases of deficiency. The experimental group improved slightly in several psychological tests, whereas subjects on placebo remained unchanged or deteriorated during the follow-up period. Clinical amelioration amongst the experimental subjects was reported by the nurses; no toxic side effects were reported. In conclusion, the elderly were benefitted biochemically and clinically by dietary antioxi-dant supplements.