2-(2＇-吡啶基)-6-甲苯并噻唑及其二氯有机锡(1V)络合物的结构与抗肿瘤活性

Structures and Antitumour Activity of 2-(2＇-Pyridyl)-6-methylben-zothiazole and Its Diorganotin Dichloride Complexes

近年来二氯有机锡(Ⅳ)含双氮配体络合物具有抗肿瘤活性的发现,不仅为人们寻找性能优良的抗癌药物开辟了新途径,而且其合成与结构的研究势必促进有机锡化学的发展。本文报道了2-(2＇-吡啶基)-6-甲苯并噻唑及其二氯·二乙基合锡(Ⅳ)反应产物的谱学表征、晶体结构和抗癌活性筛选的主要结果。

The crystal structures of the title compounds have been determined by X-ray anal- ysis on single crystals by an Enraf-Nonius CAD4 diffractometer. For the ligand L, 2-(2′- pyridyl)-6-methylbenzothiazole, C_(13)H_(10)N_2S, monoclinic, P 2_1/n, a=5.719(1), b=15.383(1), c=27.444(4), β=95.68(1)°, Z=4, R=0.034, and complex [SnEt_2CI_2L], C_(17)H_(20)SN_2- SnCl_2, monoclinic, P2_1/c, a=14.755(2), b=9.447(5), c=13.835(1), β=95.29(2)°, Z=4, R=0.067. Structure of L was solved by direct method and structure of [SnEt_2CI_2L] the heavy atom method. The S atom is cyclized either in the free ligand or in the complex which is consistent with the IR and 1~H NMR characterizations. The Sn atom is coordinated by two nitrogen atoms, cis-chlorine and trans-ethyl groups in a highly distorted octahedron with average Sn-N distance of 2.485 .