竹红菌甲素在碱性和中性溶液中的结构变化

Conversion of Hypocrellin A in Alkaline and Neutral Media

竹红菌甲素(简称甲素,HA)是从我国云南省的一种真菌——竹红菌中提取出来的主要光敏色素。竹红菌乙素(简称乙素,HB)是竹红菌中另一个比甲素少得多的光敏色素。甲素在酸性条件下可以转化成乙素,但产率不高。下面讨论甲素在碱性和中性溶液中的结构变化,提供从甲素制备乙素和I的简便方法。

When hypocrellin A (HA), 1mg/mL, was stirred for 24h in 1.5% aqueous KOH solution, HA was converted to hypocrellin B(HB) in high yield. When HA, 1mg/mL, was refluxed for 8 h in 1.5% aqueous KOH solution, HA was converted mostly to I. The structure of I was determined by MS, ~1H NMR, IR and UV-vis spectra.