用卤代乙酸酯与酰卤的格氏偶合反应合成新戊酰乙酸乙酯

Synthesis of Ethyl Pivaloylacetic Acid Ester by Grignard Coupling Reaction of Haloacetic Acid Ester with Pivaloyl Chloride

卤代乙酸酯与Mg反应形成格氏试剂后,易与酯基发生自身偶合,格氏试剂难以分离,因而很少应用于合成。M0riwake报道用卤代乙酸的叔丁酯代替乙酯,并与酮一起加入到Mg/

This paper reports a new synthetic route to ethyl pivaloylacetic acid ester by the Grignard coupling reaction of haloacetic acid ester with pivaloyl chloride in presence of magnesium. The reaction conditions and catalysts have been studied.