摘要
双氢埃托啡(1)为合成的高效镇痛剂。药理实验结果表示,其镇痛作用优于吗啡。该化合物的~1H和^(13)C NMR谱都较为复杂,尚未见报道,并且多数谱峰采用一般方法难以指定。
The ~1H and ^(13)C NMR signals of the analgesic dihydroetophine (1) were assigned by ~1H-~1H COSY-NOESY, ^(13)C-~1H COSY and lons range ^(13)C-~1H COSY techniques. According to the 2 D NOE experiment, the C-7 and C-19 configuration of the compound have been elucidated as (2). The result was confirmed by X-ray diffraction analysis.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
1989年第4期347-352,共6页
Chinese Journal of Organic Chemistry
关键词
双氢埃托啡
NMR
二维NMR
立体化学
dihydroetophine
~1H and ^(13)C NMR
two-dimentional NMR
stereochemistry