摘要
为了观察血小板活化因子(PAF)在急性低压缺氧中的作用,该课题选用了天然PAF拮抗剂Taponin来进行缺氧干预实验.结果发现,用0.5g/kg剂量灌胃给药8次,对急性低压缺氧引起的大鼠心肌、肝功能和内皮细胞损害有较好的保护作用,血液中的CPK、LDH、a-HBD、AST、ALT、γ-GT以及ET含量均未见明显升高,和对照组相比,差异无显著性(P>0.05).Taponin是从银杏树叶中提取出来的一组甙类或酯类物质,来源充分,副作用小,对急性低压缺氧引起的机体损害,可能有着广阔的预防和治疗前景.
In order to investigate the effect of PAF on acute hypobaric hypoxia, Taponin,a kind of natural anti-PAF substance,was used as a predicting experiment to ob-serve the protective effect of the anti-PAF substance against the harmful efffects of acute hypobaric hypoxia. The results showed that after gastric irrigation of Taponin 0. 5g/kg for 8 times the harmful effects of acute hypobaric hypoxia on the myocardium, hepatic functions and endothelial cells were not serious. Compared with the control group,there was no significant elevation of the contents of CPK,LDH,a-HBD,AST,ALT,γ-GT and ET(P>0. 05), which revealed that Taponin had a relatively good protective effect on acute hypobaric hypoxia. Taponin is a group of substances with the structures of glucoside and ester extracted from Ginkgo leaves, mainly including Ginkgo flavonal glycosides,Bilobalid and Ginkgolides etc. Taponin has the advantages of a rich resource and little side efffects.It has probably a wide prospect of prevention and treatrnent for the damage caused by acute hypobaric hypoxia.
