高血压、冠心病及合并糖尿病患者血浆甘丙素浓度的临床初步观察

Plasma galanin in patients with hypertension coronary heart disease with of without diabetes mellitus

用放免法检测31例原发性高血压、冠心病及冠心病合并糖尿病患者(CHDMH)血浆甘丙素水平.结果显示:病人组均高于对照组.其中以冠心病合并糖尿病组浓度最高(9.18±6.05pmol/L),单纯冠心病组最低(3.22±0.98 pmol/L),高血压病组居中(5.04±1.51 pmol/L).上述各组除单纯冠心病组外,与对用组之间经t或F-Q检验均有显著差异(P<0.01).各组血浆甘丙素水平与年龄之间相关性检验无显著意义.

All the cases of essential hypertension (EM) ,coronary heart disease (CHD)and diabetes mellitus (DM) in this article were diagnosed according to the critera of WHO ,The plasma content of galanin were determined by radioimmunoassay. The results showed that galanin in all patients was more significantly increased (5. 20±0. 74 pmol/L) than that in the contols (2.98±1.56 pmol/L,t= 9.903,P<0.001). Particularly ,patients of CMD, accompanied with ET and DM, had the highest levels of galanin (9.18±6.05 pmol/L,Q=20. 10,P<0. 01,vs other groups), whereas patients of CHD had the lowest level of galanin (3. 22± 0. 98 pmol/L) and patients of EM had the galanin level of 5.05±1.51 pmol/L.It is possible that galanin may play some role in the development of these diseases.