兔动脉粥样硬化时红细胞及血清唾液酸含量的改变

The Change of Sialic Acid Content in Erythrocytic Membrance and Serum During Atherosclerosis in Rabbits

用食饵性高血脂及食饵性高血脂加免疫性动脉内皮损伤的方法建立兔动脉粥样硬化模型,观察到随着动脉粥样硬化病变发生,红细胞膜唾液酸含量降低而血清唾液酸含量增高,与对照组比较均有显著性差异(P<0.05).动脉粥样硬化的程度与红细胞膜唾液酸含量呈显著负相关(P<0.01),与血清唾液酸含量呈显著正相关(P<0.05).实验结果提示红细胞膜和血清唾液酸含量的变化与动脉粥样硬化病变的形成及病损程度可能有密切关联.

The model of experimental atherosclerosis was established in rabbits by means of high cholesterol - feeding and high cholesterol - feeding combined with immunopathologic endothelial injuries. When atherosclerosis occurred, the content of sialic acid (SA) in the erythrocytic membrane was decreased, while the SA-content in the serum was increased, their differences were significant as compared with those in the control group (P<0.05). There was a significant negative correlation (P<0.01) of the severity of atherosclerosis with the SA-content in erythrocytic membrane but a significant positive correlation (P<0.05) with the SA-content in the serum. These results showed that the change of SA in erythrocytes and serum had an intimate relationship with the development and severity of atherosclerosis.