多肽合成中羧基活化方法的一些新进展

Some Activition of Carboxyl Group in Peptide Synthesis

本文简要叙述了多肽合成中的羧基活化问题。重点讨论了作者近年来在此领域所进行的工作,如含氮杂环作为活化羧基的离去基团和几个新的含磷多肽试剂。

The formation of peptide bond by means of activation of carboxyl group was reviewed, with emphasis on the work done by the authors recently. Various nitrogen con- taining heterocycles used as leaving groups were studied. Some new phosphorous containing reagents were used for peptide synthesis with satisfactory results.