小儿急性淋巴细胞白血病的染色体观察

CHROMOSOME NUMBERIC ABNORMALITY IN CHILDREN WITH ACUTE LYMPHOCYTIC LEUKEMIA

对9例急性淋巴细胞白血病（ALL）患儿诊断时染色体的分析，染色体数目异常检出率为6／9，观察核型与临床的关系，发现染色体数目异常（包括超二倍体核型）可视为预后差的标志。认为染色体分析对小儿ALL的疗效监测及预后评估的价值，可作为ALL的常规检查项目。

Chromosomes from 9 children suffering from acute lymphocytic Ieukemia (ALL )were analysed. It was found that 6 out of 9cases showed the numberic abnormality in chromosomes. observing the relationship between the karyotape and treatment, we noticed that the patients with chromosome numberic abnormality including hyperdiploid had bad a poor prognosis. It was dgreed that chrosomose analysis was important to evaiuate the curative cffect and prognosis of ALL in children. So we suggested that the chromosome analysis be listed as a routine examination for child cases of ALL.