^(99)Tc^(m)-HMPAO构效差异的研究──GSH水溶液中^(99)Tc^(m)-HMPAO水解动力学分析

STUDY ON STRUCTURE-ACTIVITY RELATIONSHIP OF ^(99)Tc^(m)-HMPAO──THE KINETIC ANALYSIS OF ^(99)TC^(m)-HMPAO DECOMPOSITION IN GSH SOLUTION

从化学动力学角度对ｄｌ－型和ｍｅｓｏ－型￣（９９）Ｔｃ￣ｍ－ＨＭＰＡＯ构效差异的原因进行了研究。通过测定￣（９９）Ｔｃ￣ｍ－ＨＭＰＡＯ两种异构体在ＧＳＨ和Ｌ－半胱氨酸水溶液中的解离反应的一级速率常数，比较了Ｌ－半胱氨酸和ＧＳＨ对￣（９９）Ｔｃ￣ｍ－ＨＭＰＡＯ作用，解释了ｄｌ－型和ｍｅｓｏ－型￣（９９）Ｔｃ￣ｍ－ＨＭＰＡＯ药效的差异，探讨了￣（９９）Ｔｃ￣ｍ－ｄｌ－ＨＭＰＡＯ在人脑中的贮留机理。

The structure-activity relationship of dl-and meso-￣99Tc￣m-HMPAO is chemdynamicallystudied.The first order rate constant of￣(99)Tc￣m-HMPAO decomposition in GSH solution ismeasured,and used to explain the different imaging effects of dl- and meso-￣(99)Tc￣m-HMPAO. Theretained mechanism of ￣(99)Tc￣m-dl-HMPAO in human's brain is discussed.