^（153）Gd—DTPA的合成及其在小鼠体内分布的实验研究

Synthesis and biodistribution of ￣(153)Gd-DTPA in mice

利用放射性元素１５３Ｇｄ合成１５３Ｇｄ－ＤＴＰＡ，经小鼠尾静脉注射后，取５、１５、３０、６０、１２０、１８０ｍｉｎ六个时相处死小鼠，解剖，测量各脏器放射性计数，计算得到不同时相１５３Ｇｄ－ＤＴＰＡ在各脏器的分布情况。血药清除符合二室模型，ｔ１／２（１）＝１．５ｍｉｎ、ｔ１／２（２）＝２９．９ｍｉｎ，尿液中药物排泄量ｔ１／２＝１６ｍｉｎ，３ｈ时药物９０％量在膀胱中。该药物主要通过肾脏代谢，其余脏器摄取甚少。通过１５３Ｇｄ－ＤＴＰＡ动物实验研究得到了Ｇｄ－ＤＴＰＡ的药代动力学数据。

Gd-DTPA was synthesized by 153GdCl3 and DTPA.The mice killed and biodistribution of the organs measured at 5,15,30,60,120 and 180 min post-injection. Blood 153Gd-DTPA clearence curve conformed a two-compartment open model,t1/2(1)= 1.smin,t1/2(2)= 29.gmin. Determination of urine 153Gd-DTPA concentration find: t1/2=16min.Within three hours,90 percent of the drug was concentrated in urine, thereby mainly excreated through kidney.