冠心病患者循环血中内皮细胞、内皮素和6－酮－前列环素F_（1a）的动态变化及意义

The dynamic change of endothelial cell,endothelin and 6-K-PGF_(1a) in circulating blood of the patients with coronary heart disease

以循环内皮细胞（ＣＥＣ）作为血管内皮细胞（ＶＥＣ）损伤的指示物，以血浆内皮素（ＥＴ）和前列环素（ＰＧＩ２）反映ＶＥＣ的功能变化，对８５例冠心病患者与３０例正常人进行对比研究，并对５０例不稳定型心绞痛及２０例急性心肌梗塞进行了动态观察．结果表明：冠心病外周血中ＣＥＣ、ＥＴ明显升高（Ｐ＜０．００１），ＰＧＩ２明显下降（Ｐ＜０．００１），尤以不稳定型心绞痛和急性心肌梗塞更显著，与病情的严重程度相一致．提示冠心病ＶＥＣ损伤，以及它所分泌的内皮源性舒缩因子失平衡参与了冠心病的病理过程。

With the circulating endothelial cell(CEC)as an indicator of vessel endothelial cell(VEC)injury,and plasma endothelin(ET)and prostaglandin F1a(PGI2)reflecting the functional change of the VEC,a comparative study between 85 patients with coronary heart disease and 30 normal health,and also a dynamic observation of 50 patients with unstable angina pectoris and 20 patients with acute myocardial infarction(AMI)were reported. The result showed that in patients with coronary heart disease,peripheral blood circulating CEC and ET level was increased(P<0.001),while the PGI2 decreased (P<0.01), all these were more significant in patients with unstable angina pectoris and myocardial infarction, and its magnitudecorrelated closely with the seventy of the disease. All these showed that the VEC injury and the imbalance of its endothelial relaxing and contracting factors have played an important role in the pathogenesis of coronary heart disease.