血清Ⅲ型前胶原肽对肝纤维化的诊断价值

Diagnostic significance of serum type Ⅲ procollagen Naminoterminal peptide(P Ⅲ P) in liver fibrosis

用放射免疫测定法（ＲＩＡ）检测经肝活检病理确诊的正常人、慢性迁延性肝炎（ＣＰＨ）、慢性活动性肝炎（ＣＡＨ）及肝硬变（ＨＣ）患者共３９例血清Ⅲ型前胶原肽（ＰⅢＰ），并用维多利亚兰染色对各组织切片进行胶原纤维染色并分级。结果表明：随着肝纤维化程度的增加，血清ＰⅢＰ含量也增加（ｒ＝０．５８８，Ｐ＜０．００１）；肝脏病理损伤严重的ＣＡＨ组和ＨＣ组患者血清ＰⅢＰ也显著高于正常对照组和ＣＰＨ组（Ｐ＜０．０１）。提示：血清ＰⅢＰ可以反映肝纤维化程度及活动度，作为临床判断肝病进展及转归的一项指标。

In this paper, radioimmunoassay(RIA) was used to detect the level of serum type Ⅲ Nterminal peptide of procollagen(P Ⅲ P) in 39 cases of normal persons, chronic persistent hepatitis(CPH),chronic active hepatitis(CAH) and liver cirrhosis(HC). The liver collagen fibrosis was classified with Victoria blue stain in all liver samples. The results showed that the higher the degree of liver fibrosis, the higher the serum P Ⅲ P contents in the liver and that there was a positive correlation between them (r=0.588 P<0. 001).Serum P Ⅲ P levels in CAH and cirrhosis were higher than those in CPH and normal controls(P<0.01). The results indicated that serum P Ⅲ P could reflect the degree and activity of liver fibrosis and could be used as a marker to judge the development and prognosis of liver disease.