女性生殖道疣状增生疾病中HPV感染与郎格罕氏细胞关系的研究

A Study on the Relationship of HPV and LangerhansCells in Gental Wartal Lesions

本研究应用ＡＢＣ免疫组化法，对４５例ＨＰＶ阳性及４１例阴性的生殖道疣状病变进行Ｓ－１００蛋白阳性Ｌａｎｇｅｒｈａｎｓ细胞的检测及分析。结果发现ＨＰＶ感染阳性病变的Ｓ－１００蛋白阳性ＬＣ数量为５．２４±０．８９，ＨＰＶ阴性病变Ｓ－１００蛋白阳性的ＬＣ数量为１７．１８±１．０６。二者相比较，差异有显著性，即ＨＰＶ感染阳性病变中的ＬＣ明显低于ＨＰＶ感染阴性病变中的ＬＣ，并且其ＬＣ树突状结构消失或胞突数目显著减少。我们认为ＨＰＶ感染与宿主免疫状况密切相关，ＨＰＶ感染可能抑制宿主的局部免疫功能，导致病变的发生。

In this paper,we studied the numbers and morphological changes of Langerhans cells(LCs)in 86 cases with genital warly lesions.The lesions were divided into two groups,i,e.'HPV-positive group(Group A,45 cases)and HPV-negative group(Group B,41'cases) by animmunohistochemical survey on H.PV LCs were marked by S-100 protein antibody with ABCimmunohistochemical method. The results showed that the numbers and morphologies of theS-100 protein positove LCs were markedly different in these two groups. The LCs group Awere much fewer than those in group B(PRO.05).And also,the dendritic structures of theLCs in group A decreased evidently,and even disappeared.The results suggest that the HPVinfections were closely related to the immune conditons of the host,and might suppress thelocal immune function and result in the occurrence of the warly lesions in genitals.