新有机锗倍半氧化物的合成及其抑制肿瘤活性的研究

Studies on Synthesis of New Organogermanium Sesquioxides and their Antitumour Activities

以三氯锗烷与酮或烯醇酯类反应，合成了五种未见报导的有机锗倍半氧化物（Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅴ），并用元素分析，红外光谱及核磁共振谱进行了结构表征。Ⅰ、Ⅱ、Ⅲ的生物活性测定结果表明它们具有不同程度的抑制肿瘤作用。

Five unreported germanium sesquioxides have been synthesized by reactien of germanium chloroform to ketones, vinyl or allyl acetic esters. Elemental anaysis, IR and NMR have been done for the characterization of these compounds(Ⅰ.Ⅱ.Ⅲ.Ⅳ. Ⅴ), studies on their antitumour activitics of if Ⅰ.Ⅱ and Ⅲ show some positive results.