L－精氨酸抗家兔动脉粥样硬化内皮损伤

Influence of L-Arginine on the Endothelium Lesion in Atherosclerotic Plaques in Rabbits.

将新西兰兔分成三组：正常组、高胆固醇组、高胆固醇加Ｌ－精氨酸组。分别喂养４周和８周。扫描电镜下观察到：高胆固醇组与高胆固醇加Ｌ－精氨酸组相比，内皮细胞排列不规则，细胞间隙银染较粗，内膜损伤和增生明显。说明补充Ｌ－精氨酸可减轻内膜损伤。

ew Zealand white rabbits were divided at random into three groups which were,fed a normal chow(Control) and a high-cholesterol diet(HCD)a high cholesterol diet suplemented with L-arginine(HCD-Arg)for 4 or 8weeks respectively. In the high-cholesterol diet group (vs HCD-Arg group),scanning electron microyraphs of rabbit aortic arteries stained with silver nitrate showed that endothelium cells had irregular sizes and lacked the typical alignment in the direction of blood flow.Permeability of endothelium cells of atherosclerotic plaques was increased in HCD group (vs HCD-Arg group). Meanwhile, L-arginine could partly inhibit the development of atherosclerotic plaques. These data suggest that hypercholesterolemia enhances the endothelium lesion; this effect is affenuated by dietary L-arginine.